By necessity, the register templates that are built in to ThunderPOS are a little one-size-fits-all. There are several options, and more through the template exchange in the register designer, but these will usually have functions a particular store may not need or want. What you can do is to lay out your buttons yourself.
Want repairs in your record shop, but not rentals or special orders? Have a need to simplify things for the part time employees in your game shop? This approach can get your register to have exactly what you need and no more.

This doesn’t have to mean starting from scratch; you can much more easily modify an existing design than build one from nothing. Any layout in the system or online can be edited through the designer.
One common thought is to get rid of all the functions you don’t use. Anything you decide you want later can be re-added.
Let’s say, as an example, you were a vape store that did not want to do anything with trades, used product, or customer tracking. You like the most basic register layout, but you want to remove the clutter.
The unmodified version of the register includes a lot of functionality you don’t want. Many of these elements are related to customer tracking, such as special orders or repairs.
Let’s take five to ten minutes and trim back on some of these elements in the designer, deleting things like the customer display and the tender specific checkouts, instead going for a more simple approach.

This is perhaps an extreme example, cutting this layout to the bare minimum needed. However, it’s going to make training employees far simpler, and reduce errors. The same general principle can apply if only taking off a few buttons, or making a layout that makes more sense for your store.
You can also do something a bit more drastic if you start from scratch. For example, if we want a layout where the item grid isn’t centered but rather below all of the other buttons, for the maximum width, you could do something like this:

You can, of course, combine any or all of these ideas, along with customizing the fonts and colors to match up to your store. But we would recommend giving serious thought to stripping out those features your store does not need – it will save you and your employees time in the long run. Both by making it easier to find the buttons you do need and by keeping you from hitting buttons you don’t.